How Does Kapvay Differ from Intuniv?

PostedSeptember 22, 2025

UpdatedSeptember 22, 2025

ByMy Patient Advice

Author: Avery Lombardi, MSc | Reviewed by: Dr. Rebecca Fernandez, MBBS

Both Kapvay (clonidine) and Intuniv (guanfacine) are alpha-2 agonists used to treat ADHD, but they have distinct differences in formulation, usage, and side effect profile. Understanding the nuances of Kapvay vs Intuniv can help determine which medication might be most effective for managing ADHD symptoms.

Mechanism of Action

Both Kapvay and Intuniv work by stimulating alpha-2 adrenergic receptors in the brain, which helps regulate the release of norepinephrine. This action calms hyperactivity and improves focus. However, Kapvay is based on clonidine, while Intuniv is based on guanfacine. Though both medications are alpha-2 agonists, Kapvay generally has a stronger sedative effect due to its potency in lowering blood pressure, making it potentially more effective for those who experience significant hyperactivity or impulsivity.

Primary Uses

Kapvay is primarily used for ADHD in children and adolescents, particularly when stimulants aren’t effective or cause undesirable side effects. It is also used for hypertension. Intuniv, while also used for ADHD, tends to be preferred for its longer duration of action and is typically more effective for individuals with co-occurring issues like anxiety, as it has a slightly milder sedative effect compared to Kapvay.

Side Effect Profile

In terms of side effect profile, Kapvay tends to cause more sedation and drowsiness due to its stronger blood pressure-lowering effects. Intuniv may cause some drowsiness as well but generally has a gentler calming effect, making it a better choice for individuals who need sustained symptom control without excessive sedation.

In conclusion, Kapvay vs Intuniv comes down to individual response and specific needs. Kapvay may be more suitable for those requiring stronger sedative effects, while Intuniv offers a more balanced, longer-lasting option for ADHD management.

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For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Medications for ADHD..

Avery Lombardi, MSc

Author

Avery Lombardi is a clinical psychologist with a Master’s in Clinical Psychology and a Bachelor’s in Psychology. She has professional experience in psychological assessment, evidence-based therapy, and research, working with both child and adult populations. Avery has provided clinical services in hospital, educational, and community settings, delivering interventions such as CBT, DBT, and tailored treatment plans for conditions including anxiety, depression, and developmental disorders. She has also contributed to research on self-stigma, self-esteem, and medication adherence in psychotic patients, and has created educational content on ADHD, treatment options, and daily coping strategies.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.