What Maternal Genetic and Factors Autism Are Associated with Autism Risk?

PostedNovember 27, 2025

UpdatedNovember 27, 2025

ByMy Patient Advice

Author: Hannah Smith, MSc | Reviewed by: Dr. Rebecca Fernandez, MBBS

Research into the link between maternal genetic factors and autism is expanding as scientists explore how specific genetic traits in mothers may influence the risk of autism in their children. Studies suggest that maternal genetic factors and autism are closely connected, with certain inherited genetic variations playing a role in the development of autism spectrum disorder (ASD).

Mutations and polymorphisms in certain genes are thought to contribute to autism risk when passed down from mother to child. These maternal genetic factors and autism associations indicate that changes in DNA could disrupt brain development or affect the way the nervous system functions, potentially increasing the likelihood of autism.

How Maternal Genetic Factors and Autism Affect Brain Development

Here are some ways that maternal genetic factors and autism can influence a child’s development:

Mutations linked to neurodevelopment

Mutations in genes associated with brain development may be inherited from the mother. These mutations can impact neuronal growth, connectivity, and the production of neurotransmitters that are essential for healthy brain function, potentially contributing to autism.

Polymorphisms and susceptibility to autism

Polymorphisms, or common genetic variations, may also influence autism risk. Research has found that certain polymorphisms in genes involved in the immune system, brain plasticity, or synaptic function are linked to higher autism risk in children, particularly when inherited from the mother.

Interactions between genetics and environment

The influence of maternal genetic factors and autism is not limited to genetics alone; environmental factors such as prenatal exposure to toxins, infections, or stress may also play a role. The combination of these factors can increase the likelihood of autism development in genetically predisposed children.

Visit providers like Autism Detect for personal consultations to understand how maternal genetic and factors autism may affect your child’s development and explore genetic testing and early intervention strategies.

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Maternal Health and Infections.

Hannah Smith, MSc

Author

Hannah Smith is a clinical psychologist with a Master’s in Clinical Psychology and over three years of experience in behaviour therapy, special education, and inclusive practices. She specialises in Applied Behavior Analysis (ABA), Cognitive Behavioural Therapy (CBT), and inclusive education strategies. Hannah has worked extensively with children and adults with Autism Spectrum Disorder (ASD), ADHD, Down syndrome, and intellectual disabilities, delivering evidence-based interventions to support development, mental health, and well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.