Are first-time mothers of advanced age more likely to have a child with autism? 

Emerging research is beginning to examine the connection between primiparity, advanced age and autism, suggesting that being a first-time mother at an older age may slightly increase the likelihood of autism in offspring. While autism has many contributing factors, a woman’s age during her first pregnancy is attracting attention as a possible influence. 

Studies exploring primiparity, advanced age and autism highlight the idea that the combination of being older and having a first pregnancy may create distinct challenges. These include increased inflammation during pregnancy, a higher risk of complications, and changes in immune or hormonal regulation. 

Why First-Time Pregnancies at Advanced Age Matter 

Here’s how this maternal profile may affect developmental outcomes: 

First-time mothers face distinct physiological demands  

For first-time mothers, particularly those aged 35 and above, the body’s response to pregnancy can differ from that of younger or more experienced mothers. These differences can act as maternal risk factors, shaping foetal development in subtle but important ways. 

Biological and lifestyle overlap  

Women who conceive later in life may also experience overlapping maternal risk factors, such as chronic health conditions, medication use, or prolonged exposure to environmental stressors. When combined with primiparity, advanced age and autism considerations, these factors underline the importance of attentive prenatal monitoring and care. 

Visit providers like Autism Detect for personal consultations to understand how maternal health, age, and pregnancy timing affect your child’s development and how to support effective sensory regulation and comfort. 

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Advanced Parental Age.

Hannah Smith, MSc

Author

Hannah Smith is a clinical psychologist with a Master’s in Clinical Psychology and over three years of experience in behaviour therapy, special education, and inclusive practices. She specialises in Applied Behavior Analysis (ABA), Cognitive Behavioural Therapy (CBT), and inclusive education strategies. Hannah has worked extensively with children and adults with Autism Spectrum Disorder (ASD), ADHD, Down syndrome, and intellectual disabilities, delivering evidence-based interventions to support development, mental health, and well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy. 

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.