Does aspirin use in pregnancy and autism risk change in older mothers? 

When mothers are of advanced maternal age, medical care often includes discussions about aspirin use in pregnancy and autism risk. Aspirin, particularly in low doses, is commonly prescribed to prevent conditions such as pre-eclampsia. While some studies have explored whether this could influence autism risk, the current evidence does not support a direct link. 

Experts, including the American College of Obstetricians and Gynaecologists, continue to recommend low-dose aspirin for high-risk pregnancies, citing its benefits in preventing pre-eclampsia and improving placental health, especially in older expectant mothers. Meanwhile, research into aspirin use in pregnancy and autism has produced inconclusive results: observed associations often involve confounding factors such as underlying health conditions rather than aspirin itself. 

What the research says 

Here’s what families should know about aspirin use in pregnancy and autism: 

Used for medical protection, not risk  

In women of advanced maternal age, aspirin is often prescribed to mitigate pregnancy complications. Its use is linked to improved outcomes, not increased autism risk. 

Medication safety is key  

As with all prenatal medication safety considerations, aspirin use must be balanced against maternal health factors, including the mother’s medical background and current pregnancy risks. 

Visit providers like Autism Detect for personal consultations to explore your options around aspirin use in pregnancy within the context of your age, health history, and prenatal needs. 

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Advanced Parental Age.

Hannah Smith, MSc

Author

Hannah Smith is a clinical psychologist with a Master’s in Clinical Psychology and over three years of experience in behaviour therapy, special education, and inclusive practices. She specialises in Applied Behavior Analysis (ABA), Cognitive Behavioural Therapy (CBT), and inclusive education strategies. Hannah has worked extensively with children and adults with Autism Spectrum Disorder (ASD), ADHD, Down syndrome, and intellectual disabilities, delivering evidence-based interventions to support development, mental health, and well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy. 

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.