Are there any breakthroughs in understanding the neurobiology of hyperactivity in ADHD?

PostedAugust 25, 2025

UpdatedSeptember 5, 2025

ByMy Patient Advice

Author: Victoria Rowe, MSc | Reviewed by: Dr. Rebecca Fernandez, MBBS

Recent advances in neurobiology have significantly deepened our understanding of hyperactivity in ADHD. Researchers are using cutting-edge techniques to explore brain activity, uncovering how structural and functional differences in the brain contribute to ADHD symptoms.

Through neural imaging and other tools, scientists are building a clearer picture of ADHD brain science, which could lead to more precise and effective treatments in the future.

Key Neurobiological Findings in ADHD

Here are some of the exciting breakthroughs in neurobiology research on hyperactivity:

Altered Brain Activity Patterns

Studies show that individuals with ADHD often have underactive prefrontal cortex regions responsible for attention and impulse control, and overactive regions linked to motor activity.

Structural Differences

Neural imaging reveals variations in the size and connectivity of certain brain areas, including the basal ganglia and cerebellum, which play roles in regulating movement and behaviour.

Neurotransmitter Imbalances

Imbalances in dopamine and norepinephrine signalling have been identified, helping explain impulsivity and hyperactivity.

Improved Imaging Techniques

Advanced fMRI and PET scans allow researchers to observe brain function in real time, offering new insights into how ADHD manifests neurologically.

These findings in ADHD brain science not only improve diagnosis but also guide the development of targeted therapies. Visit providers like ADHD Certify for personal consultations and to learn how these breakthroughs might influence your care.

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Hyperactivity.

Victoria Rowe, MSc

Author

Victoria Rowe is a health psychologist with a Master’s in Health Psychology and a BS in Applied Psychology. She has experience as a school psychologist, conducting behavioural assessments, developing individualized education plans (IEPs), and supporting children’s mental health. Dr. Rowe has contributed to peer-reviewed research on mental health, including studies on anxiety disorders and the impact of COVID-19 on healthcare systems. Skilled in SPSS, Minitab, and academic writing, she is committed to advancing psychological knowledge and promoting well-being through evidence-based practice.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.