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Can Bupropion Treat Both ADHD and Depression? 

PostedSeptember 3, 2025
UpdatedSeptember 3, 2025
ByMy Patient Advice

Bupropion is a medication commonly used to treat depression, but recent studies suggest it may also be effective for managing ADHD symptoms. Bupropion for ADHD and depression offers a potential solution for individuals dealing with both conditions simultaneously. Unlike stimulant medications, which are typically prescribed for ADHD, bupropion is an antidepressant that works on neurotransmitters such as dopamine and norepinephrine, which are involved in both mood regulation and attention. 

While bupropion for ADHD and depression is not the first-line treatment for ADHD, it has shown promise in cases where both disorders are present. This is due to its ability to address symptoms of depression while also providing some benefit for ADHD, such as improving concentration and reducing impulsivity. 

Dual Treatment and Off-Label Use 

Dual treatment 

Bupropion may help treat both conditions in one medication, reducing the need for multiple prescriptions. This can be particularly beneficial for individuals who struggle with medication side effects or have difficulty managing several treatments at once. 

Off-label use 

Although bupropion is not FDA-approved specifically for ADHD, its off-label use for this condition has been supported by some clinical studies and is increasingly prescribed for individuals with both ADHD and depression. 

While bupropion for ADHD and depression can be an effective option, it’s important to consult a healthcare provider to determine if it’s the right choice based on individual health needs and symptoms. 

Visit providers like ADHD Certify for personal consultations and expert advice tailored to your needs.   

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Depression.  

Harriet Winslow, BSc - My patient advice author - mypatientadvice.co.uk

Harriet Winslow, BSc

Author

Harriet Winslow is a clinical psychologist with a Bachelor’s in Clinical Psychology and extensive experience in behaviour therapy and developmental disorders. She has worked with children and adolescents with ADHD, autism spectrum disorder (ASD), learning disabilities, and behavioural challenges, providing individual and group therapy using evidence-based approaches such as CBT and DBT. Dr. Winslow has developed and implemented personalised treatment plans, conducted formal and informal assessments, and delivered crisis intervention for clients in need of urgent mental health care. Her expertise spans assessment, treatment planning, and behavioural intervention for both neurodevelopmental and mental health conditions.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS, author and a reviewer for my patient advice - mypatientadvice.co.uk

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy. 

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