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Do Antidepressants Worsen ADHD Symptoms? 

PostedSeptember 3, 2025
UpdatedSeptember 3, 2025
ByMy Patient Advice

The question of whether antidepressants worsen ADHD symptoms is a common concern. While antidepressants are primarily prescribed to treat mood disorders like depression, some individuals with ADHD wonder if these medications might exacerbate their attention-related difficulties. The antidepressants impact on ADHD symptoms can vary depending on the type of antidepressant and the individual’s response to the medication. 

Certain antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), may have minimal effect on ADHD symptoms, while others, such as tricyclic antidepressants, can sometimes worsen focus and concentration. This can happen due to the side effects of the medication, such as fatigue or sedation, which may interfere with the ability to stay focused and engaged in daily tasks. For some individuals, symptom exacerbation can occur when antidepressants cause increased drowsiness or a decrease in motivation. 

How Antidepressants Affect ADHD Symptoms 

Side effects 

Some antidepressants can cause drowsiness, weight gain, or emotional blunting, which may interfere with the management of ADHD symptoms. 

Symptom exacerbation 

In some cases, the sedating effects of certain antidepressants can make it harder to focus or stay alert, worsening attention difficulties in people with ADHD. 

It’s important to note that while antidepressants impact on ADHD symptoms can vary, these medications may still be an effective part of treatment for co-occurring ADHD and depression. Consulting with a healthcare professional can help determine the best treatment approach based on individual needs. 

Visit providers like ADHD Certify for personal consultations and expert advice tailored to your needs.   

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Depression.  

Harriet Winslow, BSc - My patient advice author - mypatientadvice.co.uk

Harriet Winslow, BSc

Author

Harriet Winslow is a clinical psychologist with a Bachelor’s in Clinical Psychology and extensive experience in behaviour therapy and developmental disorders. She has worked with children and adolescents with ADHD, autism spectrum disorder (ASD), learning disabilities, and behavioural challenges, providing individual and group therapy using evidence-based approaches such as CBT and DBT. Dr. Winslow has developed and implemented personalised treatment plans, conducted formal and informal assessments, and delivered crisis intervention for clients in need of urgent mental health care. Her expertise spans assessment, treatment planning, and behavioural intervention for both neurodevelopmental and mental health conditions.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS, author and a reviewer for my patient advice - mypatientadvice.co.uk

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy. 

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