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What Causes Depression in People with ADHD? 

PostedSeptember 2, 2025
UpdatedSeptember 2, 2025
ByMy Patient Advice

The causes of depression in ADHD often stem from a mix of brain chemistry, life stress and emotional strain. While ADHD itself does not automatically lead to depression, the daily challenges it brings, from difficulty managing tasks to strained relationships, can raise the risk considerably. Neurobiology plays a role too, with overlapping brain regions and neurotransmitter systems influencing both conditions. 

People with ADHD may face frequent frustration, criticism or setbacks, which over time can chip away at self-esteem. These experiences, combined with a tendency towards impulsivity and difficulty regulating emotions, create fertile ground for low mood. Biological risk factors, such as genetic predisposition and altered dopamine activity, further increase vulnerability. When left unaddressed, this combination can shift from temporary sadness to clinical depression. 

Key Risk Factors Behind Depression in ADHD 

Emotional dysregulation 

Mood swings can feel sudden and overwhelming. In ADHD, emotions may be intense and harder to manage, which can amplify feelings of hopelessness. 

Chronic stress 

Missed deadlines, disorganisation and interpersonal tension can lead to ongoing stress, a known trigger for depressive episodes. 

Social isolation 

Misunderstandings and frustration in relationships may cause withdrawal from friends or family, deepening feelings of loneliness. 

Neurobiological overlap 

Changes in brain structure and function, particularly in areas linked to motivation and reward, are seen in both ADHD and depression, suggesting a shared neurological basis. 

Understanding the causes of depression in ADHD is not about placing blame. It is about recognising patterns that can be changed. With the right support, including therapy, lifestyle adjustments and sometimes medication, it is possible to manage both conditions and improve quality of life. 

Visit providers like ADHD Certify for personal consultations and expert advice tailored to your needs.   

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Depression.  

Harriet Winslow, BSc - My patient advice author - mypatientadvice.co.uk

Harriet Winslow, BSc

Author

Harriet Winslow is a clinical psychologist with a Bachelor’s in Clinical Psychology and extensive experience in behaviour therapy and developmental disorders. She has worked with children and adolescents with ADHD, autism spectrum disorder (ASD), learning disabilities, and behavioural challenges, providing individual and group therapy using evidence-based approaches such as CBT and DBT. Dr. Winslow has developed and implemented personalised treatment plans, conducted formal and informal assessments, and delivered crisis intervention for clients in need of urgent mental health care. Her expertise spans assessment, treatment planning, and behavioural intervention for both neurodevelopmental and mental health conditions.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS, author and a reviewer for my patient advice - mypatientadvice.co.uk

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy. 

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