When Do ADHD Medications Start Working? 

One of the most common questions people ask when starting ADHD treatment is, “When do ADHD medications start working?” The ADHD medication onset can vary depending on the type of medication, individual response, and other factors such as dosage and administration method. 

Stimulant Medications 

For stimulant medications like methylphenidate (Ritalin) and amphetamines (Adderall), the effects are typically felt within 30 to 60 minutes of taking the medication. These medications work quickly by increasing dopamine and norepinephrine levels in the brain, improving focus, attention, and impulse control almost immediately. Time to effect can vary slightly depending on whether the medication is in immediate-release or extended-release form. Immediate-release stimulants usually show effects faster than their extended-release counterparts. 

Non-stimulant Medications 

Non-stimulant medications like atomoxetine (Strattera) and guanfacine (Intuniv) tend to have a slower onset. These medications work by regulating norepinephrine, but they typically take several days to weeks before noticeable improvements in focus and behaviour are observed. Because of this gradual action, non-stimulants may be a better option for individuals who prefer a more steady approach or have experienced side effects with stimulants. 

In conclusion, the ADHD medication onset varies depending on the type of medication used. The treatment response of stimulants and non-stimulants vary. Stimulants work quickly, while non-stimulants may take longer but provide steady, long-lasting results. 

For more information on the effectiveness and timing of ADHD medications, read our complete guide to Medications for ADHD.  

Visit providers like ADHD Certify for personal consultations and expert guidance tailored to your unique situation. 

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Medications for ADHD.

Avery Lombardi, MSc

Author

Avery Lombardi is a clinical psychologist with a Master’s in Clinical Psychology and a Bachelor’s in Psychology. She has professional experience in psychological assessment, evidence-based therapy, and research, working with both child and adult populations. Avery has provided clinical services in hospital, educational, and community settings, delivering interventions such as CBT, DBT, and tailored treatment plans for conditions including anxiety, depression, and developmental disorders. She has also contributed to research on self-stigma, self-esteem, and medication adherence in psychotic patients, and has created educational content on ADHD, treatment options, and daily coping strategies.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy. 

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.