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How do changes in brain structure and function contribute to ADHD symptoms? 

PostedAugust 18, 2025
UpdatedSeptember 4, 2025
ByMy Patient Advice
Author: Harriet Winslow, BSc | Reviewed by: Dr. Rebecca Fernandez, MBBS

Changes in brain structure and ADHD symptoms are essential for understanding how Attention Deficit Hyperactivity Disorder (ADHD) develops. Research indicates that brain changes and ADHD symptoms are deeply interconnected, with structural differences in the brain influencing the core characteristics of ADHD. These ADHD brain abnormalities affect regions responsible for attention, impulse control, and emotional regulation, directly contributing to the symptoms experienced by individuals with the condition. 

The brain changes and ADHD symptoms most commonly impact regions such as the prefrontal cortex, basal ganglia, and cerebellum. The prefrontal cortex, responsible for tasks like decision-making and attention, tends to be less active in people with ADHD, making it harder to focus and stay organised. Similarly, the basal ganglia, which helps control motor skills and emotional responses, often operates differently in individuals with ADHD, leading to impulsive behaviour and hyperactivity. Additionally, the cerebellum, which supports coordination and timing, can also show structural changes that influence how a person with ADHD responds to stimuli. 

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Common Symptoms 

Here are some common symptoms of ADHD, linked to brain structure and function differences: 

Difficulty concentrating 

Individuals with ADHD often find it challenging to focus on tasks or maintain attention during conversations. This symptom is usually linked to an underactive prefrontal cortex. 

Impulsivity and restlessness 

Impulsive behaviours, such as interrupting others or making quick decisions, are common. These are often connected to differences in the basal ganglia. 

Visit providers like ADHD Certify for personal consultations and expert guidance tailored to your unique situation. 

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Brain structure and Function. 

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Harriet Winslow, BSc - My patient advice author - mypatientadvice.co.uk
Harriet Winslow, BSc
Author

Harriet Winslow is a clinical psychologist with a Bachelor’s in Clinical Psychology and extensive experience in behaviour therapy and developmental disorders. She has worked with children and adolescents with ADHD, autism spectrum disorder (ASD), learning disabilities, and behavioural challenges, providing individual and group therapy using evidence-based approaches such as CBT and DBT. Dr. Winslow has developed and implemented personalised treatment plans, conducted formal and informal assessments, and delivered crisis intervention for clients in need of urgent mental health care. Her expertise spans assessment, treatment planning, and behavioural intervention for both neurodevelopmental and mental health conditions.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS, author and a reviewer for my patient advice - mypatientadvice.co.uk
Dr. Rebecca Fernandez, MBBS
Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.