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How do serotonin and brain structure and function relate to ADHD causes? 

PostedAugust 18, 2025
UpdatedSeptember 4, 2025
ByMy Patient Advice

Serotonin ADHD brain function is a key factor in understanding the causes of ADHD. Serotonin is a neurotransmitter that plays a crucial role in mood regulation, attention, and behaviour control. Serotonin imbalances can affect the structure and function of the brain, which can exacerbate symptoms of ADHD like impulsivity, inattention, and trouble regulating emotions. 

The prefrontal cortex, responsible for regulating attention and decision-making, is particularly influenced by serotonin levels. A serotonin imbalance ADHD can disrupt the normal functioning of this brain region, leading to difficulties in focus and impulse control. Serotonin also influences other parts of the brain related to mood regulation and emotional reactions, which adds to the behavioural issues associated with ADHD. 

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Common Symptoms Linked to Serotonin Imbalance and ADHD 

Here are some common symptoms related to serotonin ADHD brain function: 

Difficulty focusing and staying on task 

Children and adults with ADHD often find it challenging to concentrate, especially on tasks requiring sustained focus. This is commonly associated with serotonin dysregulation in the prefrontal cortex. 

Impulsivity and emotional dysregulation 

Impulsive behaviours and emotional outbursts, such as acting without thinking or difficulty controlling emotions, are common in ADHD. These behaviours are often linked to serotonin imbalance ADHD in brain regions like the basal ganglia. 

Visit providers like ADHD Certify for personal consultations and expert advice tailored to your needs.   

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Brain structure and Function.   

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Harriet Winslow, BSc - My patient advice author - mypatientadvice.co.uk

Harriet Winslow, BSc

Author

Harriet Winslow is a clinical psychologist with a Bachelor’s in Clinical Psychology and extensive experience in behaviour therapy and developmental disorders. She has worked with children and adolescents with ADHD, autism spectrum disorder (ASD), learning disabilities, and behavioural challenges, providing individual and group therapy using evidence-based approaches such as CBT and DBT. Dr. Winslow has developed and implemented personalised treatment plans, conducted formal and informal assessments, and delivered crisis intervention for clients in need of urgent mental health care. Her expertise spans assessment, treatment planning, and behavioural intervention for both neurodevelopmental and mental health conditions.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS, author and a reviewer for my patient advice - mypatientadvice.co.uk

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy. 

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