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What brain structure and function neurochemical imbalances cause ADHD?

Neurochemical imbalance ADHD is a key factor in understanding the underlying causes of ADHD. The chemicals in the brain are called neurotransmitters, which carry messages from one nerve cell to another, are important for the structure and operation of the brain. Imbalances in these chemicals, particularly dopamine, serotonin, and norepinephrine, can disrupt the development and function of key brain areas responsible for attention, impulse control, and emotional regulation, all of which are central to ADHD. 

Brain chemistry ADHD is affected by these imbalances, which impact brain regions such as the prefrontal cortex, responsible for executive functions like planning, focus, and decision-making. When neurotransmitter systems fail to regulate properly, individuals with ADHD often experience difficulties with attention, impulsivity, and emotional control, leading to the characteristic symptoms of the disorder. 

Common Symptoms Linked to Neurochemical Imbalances 

Here are some common symptoms associated with neurochemical imbalance ADHD

Difficulty focusing or maintaining attention

People with ADHD often find it hard to stay focused, particularly during tasks requiring sustained attention. This is often due to imbalances in dopamine and norepinephrine systems in the prefrontal cortex

Impulsivity and poor emotional regulation

Impulsivity and emotional outbursts are common in ADHD, linked to dopamine dysregulation in areas like the basal ganglia

Visit providers like ADHD Certify for personal consultations and expert advice tailored to your needs.   

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Brain structure and Function.   

Harriet Winslow, BSc - My patient advice author - mypatientadvice.co.uk

Harriet Winslow, BSc

Author

Harriet Winslow is a clinical psychologist with a Bachelor’s in Clinical Psychology and extensive experience in behaviour therapy and developmental disorders. She has worked with children and adolescents with ADHD, autism spectrum disorder (ASD), learning disabilities, and behavioural challenges, providing individual and group therapy using evidence-based approaches such as CBT and DBT. Dr. Winslow has developed and implemented personalised treatment plans, conducted formal and informal assessments, and delivered crisis intervention for clients in need of urgent mental health care. Her expertise spans assessment, treatment planning, and behavioural intervention for both neurodevelopmental and mental health conditions.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS, author and a reviewer for my patient advice - mypatientadvice.co.uk

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.