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What role does brain structure and function in ADHD play in causing ADHD? 

PostedAugust 15, 2025
UpdatedSeptember 4, 2025
ByMy Patient Advice

Brain structure and function in ADHD are central to understanding how the condition develops. Studies show that differences in specific brain regions and how they communicate can directly influence attention, impulse control, and activity levels, which are core traits of ADHD. These neurological variations help explain why some people experience persistent difficulties with focus, hyperactivity, or regulation of behaviour. 

Research highlights that people with ADHD often have reduced activity in the prefrontal cortex, the brain’s decision-making centre. This can result in challenges with planning, attention, and inhibition. Structural imaging also reveals differences in the size and connectivity of regions like the basal ganglia and cerebellum, which affect movement and emotional regulation. These findings strongly support the view that the causes of ADHD are deeply rooted in how the brain is wired and operates.

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Key Brain Differences in ADHD 

Here are some of the most researched and relevant brain-related differences observed in people with ADHD: 

Prefrontal Cortex Impairments 

This area helps regulate attention and decision-making. In ADHD, it tends to show delayed development and reduced activity, making tasks that require sustained focus especially difficult. Stimulant medications often target this region to help boost function. 

Basal Ganglia and Cerebellum Variations 

These areas support motor control and emotion processing. People with ADHD may have differences in size or communication pathways here, contributing to restlessness or emotional impulsivity. Treatments that enhance dopamine function can be particularly effective in these cases. 

Weaker Neural Connectivity 

Networks that link different brain regions may be underdeveloped or inefficient in ADHD. This can lead to inconsistent attention and trouble switching between tasks. Strategies like behavioural therapy or neurofeedback aim to improve these connections over time. 

Visit providers like ADHD Certify for personal consultations and expert guidance tailored to your unique situation. 

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Brain structure and Function in ADHD. 

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Harriet Winslow, BSc - My patient advice author - mypatientadvice.co.uk

Harriet Winslow, BSc

Author

Harriet Winslow is a clinical psychologist with a Bachelor’s in Clinical Psychology and extensive experience in behaviour therapy and developmental disorders. She has worked with children and adolescents with ADHD, autism spectrum disorder (ASD), learning disabilities, and behavioural challenges, providing individual and group therapy using evidence-based approaches such as CBT and DBT. Dr. Winslow has developed and implemented personalised treatment plans, conducted formal and informal assessments, and delivered crisis intervention for clients in need of urgent mental health care. Her expertise spans assessment, treatment planning, and behavioural intervention for both neurodevelopmental and mental health conditions.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS, author and a reviewer for my patient advice - mypatientadvice.co.uk

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy. 

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