Do antidepressants and autism risk relate in older mothers? 

The use of antidepressants and autism risk in older mothers is a growing area of research. Many older mothers take antidepressants to manage maternal mental health during pregnancy, but the potential impact of these medications on autism risk remains a topic of debate. While advanced maternal age is a known risk factor for autism, does the use of antidepressants independently increase that risk? 

Studies indicate that prenatal medication exposure, including antidepressants, may be linked to a higher autism risk. However, the question remains whether antidepressants and autism risk are influenced primarily by the mother’s age or if the medications themselves contribute directly to developmental outcomes. 

How antidepressants and autism risk interact with age 

Here’s what current research suggests about antidepressants and autism risk in advanced maternal age: 

The potential impact of antidepressants on autism risk  

Some studies suggest that certain antidepressants, particularly SSRIs (selective serotonin reuptake inhibitors), may increase the risk of autism in offspring. However, this risk is still debated, with some research showing no significant link. 

Maternal mental health and the need for antidepressants  

Managing maternal mental health during pregnancy is critical, and untreated depression can also negatively affect both mother and baby. The balance between managing depression and potential medication risks is an important consideration for older mothers. 

Visit providers like Autism Detect for personal consultations to understand how antidepressants and autism risk relate to advanced maternal age, and how to make informed choices about prenatal medication exposure. 

For a deeper dive into the science, diagnostic nuances, and full developmental outlook, read our complete guide to Advanced Parental Age.

Hannah Smith, MSc

Author

Hannah Smith is a clinical psychologist with a Master’s in Clinical Psychology and over three years of experience in behaviour therapy, special education, and inclusive practices. She specialises in Applied Behavior Analysis (ABA), Cognitive Behavioural Therapy (CBT), and inclusive education strategies. Hannah has worked extensively with children and adults with Autism Spectrum Disorder (ASD), ADHD, Down syndrome, and intellectual disabilities, delivering evidence-based interventions to support development, mental health, and well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy. 

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.