How do de novo mutations and parental age impact the likelihood of autism? 

The relationship between de novo mutations and parental age is an important factor in understanding the genetic causes of autism spectrum disorder (ASD). De novo mutations are spontaneous genetic changes that occur in the sperm or egg and are not inherited from either parent. These mutations are increasingly recognised as a key contributor to autism, and parental age plays a significant role in their occurrence. Studies show that de novo mutations and parental age are closely linked, with older parental age especially maternal age and sperm mutations in fathers contributing to an increased likelihood of these mutations. 

De novo mutations and parental age are particularly relevant in autism research because older parents tend to pass on a higher number of genetic variations due to age-related increases in genetic variation. Fathers, in particular, are more likely to pass on sperm mutations that occur over time, while maternal age has also been linked to an increased risk of mutations during egg development. Understanding how de novo mutations and parental age interact helps provide insights into the genetic factors contributing to autism risk. 

The Impact of Parental Age on De Novo Mutations in Autism 

Exploring how de novo mutations and parental age influence autism susceptibility provides valuable insights into the genetic factors that shape autism. 

Sperm Mutations and Autism Risk  

Sperm mutations increase with paternal age, leading to a higher chance of de novo mutations in offspring, which can contribute to the development of autism. 

Maternal Age and Genetic Variation  

Maternal age is another key factor that increases the likelihood of genetic variation in eggs, which can lead to de novo mutations that affect brain development and contribute to autism. 

If you are seeking guidance on how de novo mutations and parental age are related, or want to understand how sperm mutations, maternal age, and genetic variation impact autism risk, visit providers like Autism Detect for expert, personalised consultations. They can help explain the role of parental age in the genetic causes of autism and offer insights into potential risks based on age factors. 

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Gene Mutations and Chromosomal Variations. 

Hannah Smith, MSc

Author

Hannah Smith is a clinical psychologist with a Master’s in Clinical Psychology and over three years of experience in behaviour therapy, special education, and inclusive practices. She specialises in Applied Behavior Analysis (ABA), Cognitive Behavioural Therapy (CBT), and inclusive education strategies. Hannah has worked extensively with children and adults with Autism Spectrum Disorder (ASD), ADHD, Down syndrome, and intellectual disabilities, delivering evidence-based interventions to support development, mental health, and well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy. 

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.