Do inherited traits reduce the chances of autism caused by new mutations?

PostedNovember 20, 2025

UpdatedNovember 20, 2025

ByMy Patient Advice

Author: Beatrice Holloway, MSc | Reviewed by: Dr. Rebecca Fernandez, MBBS

When it comes to autism, the question of inherited traits vs. new mutations is complex. Both inherited genetic factors and mutation risks play key roles in determining autism likelihood, but they act in different ways. While inherited traits contribute to the genetic makeup passed down from parents, new mutations, also known as de novo mutations, are spontaneous changes in the DNA that can arise in the child, potentially leading to autism.

Inherited Traits and New Mutations

Inherited traits are genetic factors passed down from the parents, and they can either contribute to or lower the autism probability depending on family history. For example, if a child inherits a set of inherited factors that are associated with autism, it can influence the likelihood of the child developing the condition. However, these traits may sometimes mask or interact with new mutations, which could either enhance or reduce the overall risk.

Inherited traits:

Traits passed down through generations may increase the risk of autism in the family, particularly in cases where multiple family members show signs of autism.

New mutations:

On the other hand, de novo mutations that arise in a single individual can be responsible for autism in the absence of family history.

In conclusion, inherited traits vs. mutation risk are a balance of genetics. The presence of inherited traits can influence the likelihood of autism caused by new mutations, either amplifying or reducing the risk, depending on various genetic interactions.

Visit providers like Autism Detect for personal consultations to better understand autism risk and how genetics may play a role in your family history.

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to inherited traits and family history.

Beatrice Holloway, MSc

Author

Beatrice Holloway is a clinical psychologist with a Master’s in Clinical Psychology and a BS in Applied Psychology. She specialises in CBT, psychological testing, and applied behaviour therapy, working with children with autism spectrum disorder (ASD), developmental delays, and learning disabilities, as well as adults with bipolar disorder, schizophrenia, anxiety, OCD, and substance use disorders. Holloway creates personalised treatment plans to support emotional regulation, social skills, and academic progress in children, and delivers evidence-based therapy to improve mental health and well-being across all ages.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.