Is there a genetic predisposition for autism linked to maternal health?

PostedNovember 27, 2025

UpdatedNovember 27, 2025

ByMy Patient Advice

Author: Hannah Smith, MSc | Reviewed by: Dr. Rebecca Fernandez, MBBS

Understanding the connection between genetic predisposition, autism and maternal health is crucial in exploring the factors that contribute to autism. Research has shown that both genetic and environmental factors, particularly maternal health, can influence a child’s likelihood of developing autism. The role of genetic predisposition, autism and maternal health is a key area of interest for scientists seeking to identify early predictors and interventions for autism.

Many studies suggest that hereditary factors passed from the mother may play a significant role in autism risk. Additionally, epigenetics, which refers to changes in gene expression due to environmental influences, may also impact how maternal health conditions affect the developing brain. The link between genetic predisposition, autism and maternal health highlights the complex interaction between genetics and the prenatal environment.

How Genetic Predisposition, Autism and Maternal Health Influence Neurodevelopment

Here are some key ways that genetic predisposition, autism and maternal health might interact and impact foetal development:

Hereditary factors and genetic risk

Hereditary factors are often linked to autism risk. Certain genetic mutations or variations in the mother’s genes can be passed to the child, potentially increasing their risk of autism. Studies have identified genes related to brain function and immune response that may be inherited and influence neurodevelopment.

Epigenetics and the role of maternal health

Epigenetics suggests that maternal health during pregnancy can affect gene expression, even if the underlying DNA is unchanged. Conditions like maternal stress, poor nutrition, or infections can modify how genes related to brain development are expressed, affecting autism risk.

Interaction of maternal health and genetic predisposition

Maternal health factors, such as pre-existing conditions like diabetes or autoimmune disorders, can interact with a child’s genetic predisposition, amplifying autism risk. These conditions may cause inflammation or other biological changes that influence foetal brain development.

Visit providers like Autism Detect for personal consultations to understand how genetic predisposition and autism maternal health factors may affect your child’s development and explore personalised strategies for early risk assessment.

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Maternal Health and Infections.

Hannah Smith, MSc

Author

Hannah Smith is a clinical psychologist with a Master’s in Clinical Psychology and over three years of experience in behaviour therapy, special education, and inclusive practices. She specialises in Applied Behavior Analysis (ABA), Cognitive Behavioural Therapy (CBT), and inclusive education strategies. Hannah has worked extensively with children and adults with Autism Spectrum Disorder (ASD), ADHD, Down syndrome, and intellectual disabilities, delivering evidence-based interventions to support development, mental health, and well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.