What is the role of genetic polymorphisms in nutrient absorption in autism?

PostedNovember 27, 2025

UpdatedNovember 27, 2025

ByMy Patient Advice

Author: Beatrice Holloway, MSc | Reviewed by: Dr. Rebecca Fernandez, MBBS

Research suggests that genetic polymorphisms in autism may play a significant role in how the body absorbs and uses essential nutrients. These genetic differences can impact biological pathways, leading to variations in how vitamins, minerals, and other key compounds are processed. As a result, some individuals with autism may experience unique nutritional needs compared to the general population.

The study of genetic polymorphisms in autism helps explain why some children respond differently to dietary interventions or supplementation. Specific variations may influence nutrient absorption, limiting the body’s ability to use nutrients efficiently. This, in turn, can affect energy balance, growth, and brain function. Since many of these processes are tied to metabolism, understanding the genetic component is vital for more targeted dietary planning.

How Genetic Polymorphisms Influence Nutrition

Genetic variations can shape how the body processes and distributes nutrients. Below are key areas where differences are often seen:

Folate and B-Vitamins

Polymorphisms affecting enzymes involved in folate pathways may reduce the availability of these nutrients for brain and cellular function.

Fatty Acids

Some variations can limit the body’s ability to process essential fatty acids, which are important for cognitive and emotional regulation

Detoxification and Antioxidants

Certain genetic changes may affect how toxins are cleared, increasing demand for nutrients that support antioxidant defences.

By identifying how genetic polymorphisms in autism alter nutrient use, families and healthcare providers can design more individualised interventions that support overall wellbeing.

Visit providers like Autism Detect for personal consultations.

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to nutritional deficiencies.

Beatrice Holloway, MSc

Author

Beatrice Holloway is a clinical psychologist with a Master’s in Clinical Psychology and a BS in Applied Psychology. She specialises in CBT, psychological testing, and applied behaviour therapy, working with children with autism spectrum disorder (ASD), developmental delays, and learning disabilities, as well as adults with bipolar disorder, schizophrenia, anxiety, OCD, and substance use disorders. Holloway creates personalised treatment plans to support emotional regulation, social skills, and academic progress in children, and delivers evidence-based therapy to improve mental health and well-being across all ages.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.