Do Dopamine/Norepinephrine Therapies Help ADHD in Older Adults? 

ADHD is not just a childhood disorder; it can persist into adulthood, with many individuals experiencing symptoms in their later years. For older adults with ADHD, managing symptoms can become more complex due to changes in the ageing brain. However, therapies targeting dopamine and norepinephrine, the two key neurotransmitters involved in ADHD, are effective in managing late-life ADHD, even in older individuals. 

Dopamine/Norepinephrine Imbalances in Older Adults 

As the brain ages, there are natural declines in dopamine and norepinephrine activity, particularly in areas like the prefrontal cortex and basal ganglia, which are involved in attention, motivation, and executive function. In older adults with ADHD, these natural changes can exacerbate difficulties with focus, decision-making, and impulse control, making the symptoms of ADHD harder to manage without intervention. 

Medication Response in Older Adults 

Dopamine and norepinephrine-based therapies, such as stimulants and non-stimulants (e.g., methylphenidate and atomoxetine), are commonly used in ADHD treatment. These medications work by increasing the availability of dopamine and norepinephrine in the brain, improving attention, focus, and self-regulation. In older adults, these therapies can be highly effective, though dosage adjustment may be necessary due to changes in metabolism and the body’s response to medications over time. 

While older adults with ADHD may experience a slightly different response to medication compared to younger individuals, research shows that dopamine/norepinephrine therapies can still provide significant benefits in reducing cognitive and emotional symptoms in late-life ADHD. Visit providers like ADHD Certify for personal consultations to learn how dopamine and norepinephrine therapies can help manage ADHD in older adults  

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Dopamine and norepinephrine systems.

Victoria Rowe, MSc

Author

Victoria Rowe is a health psychologist with a Master’s in Health Psychology and a BS in Applied Psychology. She has experience as a school psychologist, conducting behavioural assessments, developing individualized education plans (IEPs), and supporting children’s mental health. Dr. Rowe has contributed to peer-reviewed research on mental health, including studies on anxiety disorders and the impact of COVID-19 on healthcare systems. Skilled in SPSS, Minitab, and academic writing, she is committed to advancing psychological knowledge and promoting well-being through evidence-based practice.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy. 

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.