Are epigenetic markers reversible in ADHD?

PostedOctober 8, 2025

UpdatedOctober 10, 2025

ByMy Patient Advice

Author: Victoria Rowe, MSc | Reviewed by: Dr. Rebecca Fernandez, MBBS

Yes, one of the most promising aspects of reversible ADHD epigenetics is that these biological changes are not necessarily permanent. Unlike genetic mutations, which are hardcoded, epigenetic markers like DNA methylation or histone modifications can be altered by environment, behaviour, and treatment. This opens the door to new strategies that target brain plasticity and long-term improvement in symptoms.

What makes epigenetics reversible?

Epigenetic processes act like dimmer switches for gene activity. Factors such as stress, toxins, nutrition, and medication can influence whether genes are switched on or off, but crucially, these switches can also be turned back.

Therapeutic interventions

Behavioural therapy, medication, exercise, and even sleep improvements can reshape brain activity, and in some cases, shift the epigenetic patterns associated with ADHD.

Nutrition and supplements

Nutrients like folate, choline, and omega-3 fatty acids play a key role in methylation. Supporting methylation nutritional pathways may help rebalance gene expression over time.

Mind-body practices

Stress reduction techniques, including mindfulness, yoga, and biofeedback, have shown potential to influence epigenetic markers related to stress and emotional regulation, both of which are core to ADHD.

Why this matters for treatment

The idea that epigenetic markers are reversible reframes ADHD from a fixed neurological condition to one shaped by both biology and environment and responsive to change. This supports a more dynamic view of treatment, not just managing symptoms but actively reshaping the biological terrain over time.

Visit providers like ADHD Certify for personal consultations that explore the intersection of treatment and epigenetic change.

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Genetic studies and biomarkers.

Victoria Rowe, MSc

Author

Victoria Rowe is a health psychologist with a Master’s in Health Psychology and a BS in Applied Psychology. She has experience as a school psychologist, conducting behavioural assessments, developing individualized education plans (IEPs), and supporting children’s mental health. Dr. Rowe has contributed to peer-reviewed research on mental health, including studies on anxiety disorders and the impact of COVID-19 on healthcare systems. Skilled in SPSS, Minitab, and academic writing, she is committed to advancing psychological knowledge and promoting well-being through evidence-based practice.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.