Are there shared genetic markers between ADHD and bipolar disorder?

PostedAugust 19, 2025

UpdatedSeptember 4, 2025

ByMy Patient Advice

Author: Lucia Alvarez, MSc | Reviewed by: Dr. Rebecca Fernandez, MBBS

Yes, current research supports the existence of overlapping genetic markers between ADHD and bipolar disorder. The study of ADHD and bipolar genetics is shedding light on how shared neurobiological traits can increase the likelihood of both conditions developing in the same individual.

Though ADHD is typically characterised by impulsivity and inattention, and bipolar disorder by mood swings and energy shifts, some genetic similarities help explain their frequent co-occurrence, especially in adolescent and adult populations.

What the research shows about shared genetics

Shared genetic markers between ADHD and bipolar disorder reveal why the two conditions sometimes present together and how they influence each other.

Bipolar overlap

Genome-wide association studies have identified risk loci that contribute to both disorders. This bipolar overlap suggests that disruptions in brain pathways related to mood regulation and executive function are common to both.

Psychiatric genes

Several psychiatric genes, including those linked to dopamine and glutamate systems, have been implicated in both ADHD and bipolar disorder. These genes affect emotional reactivity and cognitive control, contributing to overlapping symptoms.

ADHD comorbidity patterns

Individuals with ADHD may be at higher risk for developing bipolar disorder, particularly when impulsivity is prominent. This ADHD comorbidity highlights the importance of careful differential diagnosis and comprehensive treatment planning.

Understanding ADHD and bipolar genetics helps clinicians distinguish between the two conditions and manage their intersection more effectively. Visit providers like ADHD Certify for guidance on accurate diagnosis and dual-disorder care.

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Genetic Factors in ADHD.

Lucia Alvarez, MSc

Author

Lucia Alvarez is a clinical psychologist with a Master’s in Clinical Psychology and extensive experience providing evidence-based therapy and psychological assessment to children, adolescents, and adults. Skilled in CBT, DBT, and other therapeutic interventions, she has worked in hospital, community, and residential care settings. Her expertise includes grief counseling, anxiety management, and resilience-building, with a strong focus on creating safe, supportive environments to improve mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.