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What are the genetic factors contributing to ADHD?

PostedAugust 15, 2025
UpdatedSeptember 3, 2025
ByMy Patient Advice

Research shows that genetic causes of ADHD play a major role in the development of the condition. Studies involving twins, families, and large-scale genetic mapping have revealed that ADHD tends to run in families, suggesting a strong hereditary component. In fact, children with a parent or sibling diagnosed with ADHD are significantly more likely to develop the condition themselves. 

The likelihood of inherited ADHD stems from a combination of multiple genes rather than a single genetic mutation. These genes are thought to influence brain development and the regulation of neurotransmitters like dopamine and norepinephrine, both of which affect attention, impulse control, and emotional regulation. 

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What does science say about ADHD genetics? 

Researchers continue to explore how genetic patterns affect ADHD traits. Here are some key insights. 

ADHD family history 

Having a close relative with ADHD is one of the strongest predictors of a diagnosis, pointing to the condition’s familial nature. 

Risk genes for ADHD 

Genes related to dopamine transport and receptor function, such as DRD4 and DAT1, have been repeatedly linked to ADHD symptoms. These risk genes for ADHD may alter how efficiently the brain processes rewards, attention cues, and emotional signals. 

Gene-environment interactions 

While genes set the stage, environmental factors like stress, prenatal exposure to toxins, or low birth weight can influence how those genes are expressed, intensifying or reducing ADHD traits. 

Understanding the genetic causes of ADHD doesn’t just offer answers; it also opens the door to more targeted treatment and early intervention for those at higher risk.  

Visit providers like ADHD Certify to learn how genetic history might inform your diagnosis and management plan. 

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Genetic Factors in ADHD. 

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Lucia Alvarez, MSc, author for my patient advice - mypatientadvice.co.uk

Lucia Alvarez, MSc

Author

Lucia Alvarez is a clinical psychologist with a Master’s in Clinical Psychology and extensive experience providing evidence-based therapy and psychological assessment to children, adolescents, and adults. Skilled in CBT, DBT, and other therapeutic interventions, she has worked in hospital, community, and residential care settings. Her expertise includes grief counseling, anxiety management, and resilience-building, with a strong focus on creating safe, supportive environments to improve mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy. 

Dr. Rebecca Fernandez, MBBS, author and a reviewer for my patient advice - mypatientadvice.co.uk

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy. 

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