How Does ADHD Affect Brain Lateralization on MRI?

PostedOctober 6, 2025

UpdatedOctober 6, 2025

ByMy Patient Advice

Author: Phoebe Carter, MSc | Reviewed by: Dr. Rebecca Fernandez, MBBS

Research shows that ADHD brain lateralization is often altered, with significant hemispheric asymmetry and cortical differences revealed through imaging studies such as MRI. These findings suggest that the left and right sides of the brain may not develop or function in the same way in ADHD compared to neurotypical individuals.

Structural MRI findings indicate that certain cortical regions, including parts of the prefrontal cortex, temporal lobes, and parietal areas, often show asymmetrical volume or morphologic features in people with ADHD. For example, young adults with ADHD have demonstrated cortical thinning in fronto‑parieto‑temporal regions, along with reduced surface area and alterations in gyrification. These cortical differences may persist into adulthood and may reflect a developmental delay in how brain lateralization matures.

Common Symptoms Related to Altered Lateralization

Below are symptoms often linked with these asymmetry and cortical findings, and how treatment may help:

Uneven Attention Bias

Some individuals with ADHD may show a preference or bias toward one side in attention tasks or have slower processing of stimuli presented in one visual field versus the other. Medication (particularly stimulants) can often help by enhancing interhemispheric communication, and CBT can support strategies that improve attentional switching and awareness.

Executive Function and Impulse Control Difficulties

Asymmetry in the prefrontal cortex or related regions may lead to trouble with planning, decision‑making, or resisting impulsive responses. Therapies focused on executive functioning (including CBT) combined with medication tend to be most effective here.

Visit providers like ADHD Certify for personal consultations tailored to your ADHD care and support needs.

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to ADHD brain lateralization.

Phoebe Carter, MSc

Author

Phoebe Carter is a clinical psychologist with a Master’s in Clinical Psychology and a Bachelor’s in Applied Psychology. She has experience working with both children and adults, conducting psychological assessments, developing individualized treatment plans, and delivering evidence-based therapies. Phoebe specialises in neurodevelopmental conditions such as autism spectrum disorder (ASD), ADHD, and learning disabilities, as well as mood, anxiety, psychotic, and personality disorders. She is skilled in CBT, behaviour modification, ABA, and motivational interviewing, and is dedicated to providing compassionate, evidence-based mental health care to individuals of all ages.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy.

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.