Can PET Scans Detect Dopamine and Norepinephrine Differences in ADHD? 

Yes, PET scans (Positron Emission Tomography) are among the most powerful tools for detecting dopamine and norepinephrine differences in the brains of individuals with ADHD. Unlike structural imaging, PET allows researchers to observe neurochemical imaging in real time, specifically how neurotransmitters behave, how much is available, and how well receptors and transporters are functioning. 

How PET Scans Work in ADHD Research 

PET scans use tracer studies, where a small amount of radioactive substance is injected into the bloodstream and binds to specific neurotransmitter targets, such as dopamine transporters or receptors. These tracers emit signals that the PET scanner detects, allowing scientists to visualise receptor binding, transporter density, and neurotransmitter activity in various brain regions. 

Dopamine Findings in ADHD 

PET studies have consistently shown that individuals with ADHD tend to have lower dopamine transporter binding in the striatum, which may indicate reduced dopamine availability. This underactivity is linked to symptoms such as inattention and poor impulse control. Some studies also show reduced D2/D3 receptor availability, suggesting inefficient dopamine signalling in key areas related to motivation and cognitive control. 

Norepinephrine and PET Imaging 

While more challenging to study than dopamine, norepinephrine pathways have also been explored using PET. Preliminary findings suggest alterations in norepinephrine transporter activity, especially in the prefrontal cortex and locus coeruleus, which may underlie issues with alertness and attention regulation in ADHD. 

Visit providers like ADHD Certify for personal consultations to learn how PET scans can reveal dopamine and norepinephrine differences in ADHD.

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Dopamine and norepinephrine systems.