What Brain Regions Are Implicated in ADHD Combined Type?  

The neurodevelopmental disorder known as attention deficit hyperactivity disorder (ADHD) is typified by recurrent patterns of impulsivity, hyperactivity, and inattention. ADHD reflects clear differences in brain structure and function rather than a behavioural weakness. Specifically, combined Type ADHD, which involves both inattentive and hyperactive-impulsive symptoms, is linked to changes in specific brain regions 

How ADHD Affects the Brain 

The ADHD brain exhibits differences in both structure and function compared to neurotypical brains. Key neurotransmitters, particularly dopamine and noradrenaline, significantly influence attention, motivation, and executive function. Dysregulation of these neurotransmitters produces the hallmark symptoms of ADHD. Additionally, brain imaging research has shown that people with ADHD often show differences in brain activity and volume in regions associated with self-regulation and attention. 

What Is the Combined Type of ADHD? 

Combined Type ADHD is diagnosed when an individual exhibits multiple symptoms of both inattention and hyperactivity-impulsivity. In contrast to other ADHD presentations, this subtype may involve a more extensive brain-network difference. Gaining knowledge of the neural foundations of Combined Type ADHD helps to explain its intricate symptomatology. 

Brain Regions Implicated in ADHD Combined Type 

Prefrontal Cortex 

Planning, decision-making, and impulse control depend on the prefrontal cortex. Executive function problems are a result of this region’s frequent underactivity or delayed development of ADHD. Research suggests that people with ADHD often have a smaller prefrontal cortex, which can impair behavioural control and attention. 

Basal Ganglia 

The basal ganglia are involved in coordinating movement and attention. Irregularities in this area have been linked to hyperactivity and impulsivity in ADHD. According to research structural variations in the basal ganglia may reduce the ability to focus and regulate behaviour. 

Cerebellum 

Traditionally associated with motor coordination, the cerebellum also contributes to cognitive functions like attention and language processing. According to new research, people with ADHD might have reduced volume in particular areas of the cerebellum, which could be connected to problems with coordination and cognitive function. 

Default Mode Network (DMN) 

The Default Mode Network (DMN) is active during rest and mind-wandering.  In ADHD, the DMN can be overactive or insufficiently suppressed during tasks that require sustained focus, leading to greater distractibility. This unusual activity may disrupt focus and involvement in the task. 

How Brain Activity Differs in Combined Type 

Both inattentive and hyperactive-impulsive symptoms are linked to neural patterns in people with Combined Type ADHD. Brain-imaging studies show broader and more complex variations in this subtype, mirroring its wider range of symptoms. These findings confirm that neurobiology rather than personal failings underlies these difficulties. 

What Brain Imaging Tells Us About ADHD 

Functional Differences 

Studies using EEG and functional MRI (fMRI) have shown that people with ADHD often show reduced activity in brain regions that govern focus and attention during tasks. Disruptions in the brain’s reward circuitry may also contribute to difficulties with motivation and sustained attention. 

Structural Differences 

People with ADHD have smaller brain volumes in certain regions, especially in the cerebellum and prefrontal cortex, according to structural brain imaging. Some of the behavioural and cognitive symptoms of the disorder may be linked to delayed brain development in certain areas. 

Final Thoughts 

Combined Type ADHD involves distinct and consistent changes in brain structure and function. Understanding these neurological variations confirms the experiences of people with ADHD and emphasises the significance of customised interventions. Ongoing advances in ADHD neuroscience continue to clarify the condition and promise more effective support and therapies.