Are There Salivary Biomarkers Linked to ADHD? 

As research into ADHD biomarkers advances, salivary testing is gaining attention for its non-invasive and practical appeal, especially in children. Saliva is rich in measurable compounds, including stress hormones and immune markers, making it an attractive source for identifying potential biological indicators of ADHD. 

Cortisol and Stress Hormones 

One of the most studied salivary biomarkers in ADHD is cortisol, the body’s primary stress hormone. Children with ADHD often show blunted cortisol responses to stress, particularly those with emotional dysregulation or comorbid anxiety. This dysregulation suggests that HPA axis function (the system controlling stress responses) may differ in ADHD. Measuring cortisol levels through saliva can help researchers track how stress responses vary in children with and without the disorder. 

Other Salivary Indicators 

Beyond cortisol, saliva may contain other relevant markers such as alpha amylase, an enzyme linked to sympathetic nervous system activity. Some studies have found that individuals with ADHD show altered levels of these markers, indicating changes in arousal and alertness systems tied to dopamine and norepinephrine signalling. There is also interest in immune markers found in saliva, as inflammation has been implicated in some ADHD profiles. 

Conclusion 

While still experimental, salivary biomarkers could become valuable tools for non-invasive ADHD screening, especially for children. Their ease of collection and potential to reflect stress and neurochemical regulation make them promising candidates for future diagnostic support. 

Visit providers like ADHD Certify for personal consultations and updates on salivary testing and emerging non-invasive diagnostic tools. 

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Genetic studies and biomarkers.