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Can ADHD symptoms be linked to the BDNF gene? 

PostedOctober 7, 2025
UpdatedOctober 7, 2025
ByMy Patient Advice

Yes, growing evidence shows that the BDNF gene ADHD connection could play a key role in understanding the condition’s cognitive and behavioural roots. The brain-derived neurotrophic factor (BDNF) gene helps support neural development, learning, and memory in all areas where people with ADHD often experience challenges.

BDNF acts like a fertiliser for the brain, encouraging healthy growth of neurons and supporting communication between them. When variations occur in this gene, it can disrupt these processes, potentially influencing the way attention, emotion, and executive function develop. These disruptions may help explain why some individuals with ADHD have persistent difficulties in cognition, such as working memory and processing speed. 

How the BDNF Gene Affects ADHD Traits 

Here are some of the ways BDNF gene variations might contribute to ADHD symptoms and treatment outcomes: 

Weaker working memory and learning capacity  

BDNF is vital for forming new connections in the brain. Low expression or certain variants of the BDNF gene have been linked to difficulties in memory retention and learning tasks. Cognitive Behavioural Therapy (CBT) and executive function coaching can help build strategies that support these areas. 

Slower or altered neural development 

 Children with ADHD who carry BDNF gene variants may show delays in emotional regulation or focus. These differences can influence how quickly they adapt to school environments. Early intervention and supportive learning environments can help bridge these developmental gaps. 

Variable treatment response  

Some studies suggest that BDNF variations could affect how well a person responds to medication or therapy. Understanding this gene’s role could one day enable more personalised, effective treatment strategies. Visit providers like ADHD Certify for personal consultations tailored to your genetic and cognitive profile.

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Genetic studies and biomarkers.

Victoria Rowe, MSc, author for my patient advice - mypatientadvice.co.uk

Victoria Rowe, MSc

Author

Victoria Rowe is a health psychologist with a Master’s in Health Psychology and a BS in Applied Psychology. She has experience as a school psychologist, conducting behavioural assessments, developing individualized education plans (IEPs), and supporting children’s mental health. Dr. Rowe has contributed to peer-reviewed research on mental health, including studies on anxiety disorders and the impact of COVID-19 on healthcare systems. Skilled in SPSS, Minitab, and academic writing, she is committed to advancing psychological knowledge and promoting well-being through evidence-based practice.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy. 

Dr. Rebecca Fernandez, MBBS, author and a reviewer for my patient advice - mypatientadvice.co.uk

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy. 

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