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What is the link between genetic testing and personalised ADHD care? 

PostedOctober 8, 2025
UpdatedOctober 10, 2025
ByMy Patient Advice

As science evolves, ADHD personalised treatment is shifting from trial-and-error prescribing to more informed, targeted strategies. At the centre of this shift is pharmacogenomic testing, a tool that uses a person’s genetic profile to guide decisions about medication and tailored therapy. 

While still in its early stages, this form of precision medicine holds real potential for improving how we diagnose and manage ADHD, particularly for those who have struggled with side effects or non-response. 

Take the online ADHD test

How genetic testing informs ADHD treatment 

Genetic testing can guide ADHD treatment by identifying how an individual’s genes may influence their response to different medications. 

Predicting drug metabolism  

Genes like CYP2D6 (for atomoxetine) and CES1 (for methylphenidate) affect how fast or slowly someone processes certain medications. Testing can identify whether a person is a poor, intermediate, or ultra-rapid metaboliser, which can impact both effectiveness and side effects. 

Targeting treatment based on neurobiology  

Dopamine-related genes such as DRD4, COMT, and DAT1 influence how the brain responds to stimulant medications. While findings here are still emerging, these markers may eventually help match a person to the treatment most compatible with their neurochemical profile. 

Avoiding trial-and-error  

For people who have tried multiple medications with limited success, genetic testing offers a way to refine choices and reduce unnecessary drug switches, improving the chance of finding a suitable therapy faster. 

What is next in personalised ADHD care? 

Although not yet mainstream, the link between genetics and ADHD treatment is growing stronger. As research progresses and testing becomes more accessible, pharmacogenomic insights could become part of routine ADHD management, especially for complex or treatment-resistant cases. 

Visit providers like ADHD Certify for personal consultations that incorporate the latest in precision medicine and tailored ADHD support. 

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Genetic studies and biomarkers.

Take the online ADHD test
Victoria Rowe, MSc, author for my patient advice - mypatientadvice.co.uk

Victoria Rowe, MSc

Author

Victoria Rowe is a health psychologist with a Master’s in Health Psychology and a BS in Applied Psychology. She has experience as a school psychologist, conducting behavioural assessments, developing individualized education plans (IEPs), and supporting children’s mental health. Dr. Rowe has contributed to peer-reviewed research on mental health, including studies on anxiety disorders and the impact of COVID-19 on healthcare systems. Skilled in SPSS, Minitab, and academic writing, she is committed to advancing psychological knowledge and promoting well-being through evidence-based practice.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy. 

Dr. Rebecca Fernandez, MBBS, author and a reviewer for my patient advice - mypatientadvice.co.uk

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy. 

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