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How Neuroimaging Detects Emotional Regulation Issues in ADHD 

PostedOctober 28, 2025
UpdatedOctober 28, 2025
ByMy Patient Advice
Author: Phoebe Carter, MSc | Reviewed by: Dr. Rebecca Fernandez, MBBS

Recent neuroimaging studies have enhanced our understanding of how ADHD affects emotional regulation. By using fMRI, MEG, and PET scans, researchers have identified specific brain activity patterns that underlie emotional volatility and impulsivity in individuals with ADHD. These findings are crucial for refining both diagnostic and treatment strategies. 

PFC–Amygdala Connectivity and Emotional Dysregulation 

  • fMRI meta-analyses (2024) confirm that reduced connectivity between the prefrontal cortex (PFC) and amygdala in ADHD is linked to emotional impulsivity and poor frustration tolerance. Frontiers in Psychiatry, 2024 
  • Research from University of Cambridge & UCL (2023–2024) using MEG and fMRI revealed that poor synchronisation between the PFC and amygdala is a robust indicator of ADHD-related emotional reactivity. BMJ Mental Health, 2023 

Reduced Prefrontal Cortex Activation 

  • UK fMRI studies (2024) consistently show blunted PFC responses during tasks requiring emotional regulation, contributing to mood swings and impulsivity. 

Dopamine/Norepinephrine Imbalance in Emotional Circuits 

  • Neuroimaging evidence has shown dopaminergic and noradrenergic dysfunction in ADHD, specifically in the PFC and ventral striatum, leading to emotional instability. PMC12130550, 2025 

Treatment Implications from Neuroimaging Data 

  • Stimulant medications help restore PFC function by increasing dopamine/norepinephrine availability, thus improving emotional regulation. NICE NG87, 2025 
  • CBT and Mindfulness therapies increase PFC engagement during emotional tasks, supporting better emotion regulation and stress tolerance. Frontiers in Psychiatry, 2024 

Lived-Experience Insights 

  • According to Mind (2024), individuals with ADHD report feeling “emotionally flooded” when overwhelmed, which matches neuroimaging findings showing PFC under-activation during emotional stress. Mind, 2024 
  • ADHD UK (2024) highlights the need for structured breaks and mindfulness to help modulate strong emotional reactions. ADHD UK, 2024 

Takeaway 

Neuroimaging confirms that ADHD emotional dysregulation is linked to reduced PFC activation and PFC-amygdala connectivity, driven by dopamine and norepinephrine imbalances. Treatments like medications and psychological therapies (CBT, mindfulness) help improve emotional control by restoring PFC function, offering practical benefits in daily life and enhancing overall emotional stability. 

Phoebe Carter, MSc
Author

Phoebe Carter is a clinical psychologist with a Master’s in Clinical Psychology and a Bachelor’s in Applied Psychology. She has experience working with both children and adults, conducting psychological assessments, developing individualized treatment plans, and delivering evidence-based therapies. Phoebe specialises in neurodevelopmental conditions such as autism spectrum disorder (ASD), ADHD, and learning disabilities, as well as mood, anxiety, psychotic, and personality disorders. She is skilled in CBT, behaviour modification, ABA, and motivational interviewing, and is dedicated to providing compassionate, evidence-based mental health care to individuals of all ages.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy. 

Dr. Rebecca Fernandez, MBBS, author and a reviewer for my patient advice - mypatientadvice.co.uk
Dr. Rebecca Fernandez, MBBS
Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy.