What are common side effects of ADHD medications related to mood? 

Medication can be life-changing for people with ADHD, helping improve focus, attention, and self-control. But because ADHD medicines act on the brain’s chemical systems that also regulate emotion, mood-related side effects can sometimes appear. These are usually temporary and manageable but are important to monitor closely with a clinician. 

Common mood effects of stimulant medications 

Stimulants like methylphenidate (Ritalin, Concerta), lisdexamfetamine (Elvanse), and amphetamine salts (Adderall) are the most widely used ADHD medicines. While they often improve emotional stability, they can also cause side effects such as: 

• Irritability or restlessness 

• Anxiety or tension 

• “Rebound” mood dips when medication wears off 

• Emotional blunting (feeling flat or detached) 

According to the Cleveland Clinic (2024), these mood changes are often dose-related and temporary. Adjusting timing or switching to extended-release formulations can smooth out emotional highs and lows. 

Non-stimulant medications and mood 

Non-stimulants such as atomoxetine (Strattera), guanfacine (Intuniv), and clonidine tend to have a gentler effect on emotions but may still cause: 

• Fatigue or drowsiness 

• Low mood 

• Irritability or agitation 

• Sleep disturbance 

The Mayo Clinic notes that non-stimulants are often preferred for people with anxiety or mood sensitivity, though mild low mood or sedation can occur during early treatment. 

NHS and NICE guidance 

Both NHS and NICE NG87 highlight that emotional lability, irritability, and anxiety are recognised side effects of stimulant medications, particularly in children. They recommend regular monitoring of mood and wellbeing and switching to a different medication or dose if symptoms persist. 

Why mood side effects happen 

Research published in PubMed (2024) and Frontiers in Psychiatry (2023) suggests that mood symptoms often stem from fluctuations in dopamine and norepinephrine, the same neurotransmitters responsible for attention and motivation. When medication wears off too quickly, dopamine levels can drop sharply, causing irritability or sadness. 

Managing emotional side effects 

The Royal College of Psychiatrists (RCPsych) advises that if emotional blunting, tearfulness, or irritability persist beyond the first few weeks, clinicians should review the dose or consider switching medication. Families can support by tracking daily mood patterns and noting when side effects occur. 

Practical steps include: 

• Starting at a low dose and increasing gradually 

• Using slow-release medications to prevent rebound effects 

• Maintaining consistent sleep and meal routines 

• Combining medication with CBT or emotional regulation therapy 

The NHS advises contacting your GP if mood changes persist or interfere with daily life dose adjustments are often simple and effective. 

Takeaway 

Most ADHD medications improve mood and focus overall, but emotional side effects such as irritability or low mood can occur, especially early in treatment. With careful monitoring, slow titration, and good communication with your care team, these effects can be minimised, helping the benefits of treatment outweigh the challenges.