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Do genetic factors influence the severity of ADHD symptoms differently by gender? 

PostedAugust 19, 2025
UpdatedSeptember 4, 2025
ByMy Patient Advice

A clear understanding of ADHD severity gender genetics is essential to support individuals effectively, both in families and clinical settings. Research indicates that genetic predispositions can interact with gender, leading to differences in how severe ADHD symptoms manifest in males and females. These variations help explain why boys often exhibit more overt hyperactivity, while girls may struggle with emotional regulation or inattentive symptoms. 

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How gender and genetics shape ADHD severity 

Genetic factors don’t act in isolation; they intertwine with gender in unique ways. Here’s how this plays out. 

Symptom intensity varies  

Genetic variants linked to dopamine and serotonin may express differently depending on sex-linked hormonal influences. This often results in boys showing more externalising behaviours (like physical impulsivity), while girls may display internalised symptoms such as emotional dysregulation and inattentiveness. 
  

Inherited risk variation 

Some studies suggest that females may need a higher load of risk genes to show similar ADHD symptoms as males, possibly due to protective genetic or hormonal factors. This risk variation may result in later diagnoses for girls and missed support opportunities. 
  

Behavioural genetics insights 

Twin and family research reveals that genetic heritability of ADHD severity can differ by gender. Girls with ADHD are more likely to have co-occurring anxiety or depression, reflecting shared genetic traits, while boys are more often present with externalising issues like conduct disorder. 
  

Recognising the influence of ADHD severity gender genetics helps guide more accurate, gender-responsive assessments and interventions. Visit providers like ADHD Certify for in-depth evaluations that consider gender, genetic background, and symptom profile. 

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Genetic Factors in ADHD. 

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Lucia Alvarez, MSc, author for my patient advice - mypatientadvice.co.uk

Lucia Alvarez, MSc

Author

Lucia Alvarez is a clinical psychologist with a Master’s in Clinical Psychology and extensive experience providing evidence-based therapy and psychological assessment to children, adolescents, and adults. Skilled in CBT, DBT, and other therapeutic interventions, she has worked in hospital, community, and residential care settings. Her expertise includes grief counseling, anxiety management, and resilience-building, with a strong focus on creating safe, supportive environments to improve mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy. 

Dr. Rebecca Fernandez, MBBS, author and a reviewer for my patient advice - mypatientadvice.co.uk

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy. 

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