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How do genetic factors contribute to ADHD and anxiety comorbidity? 

PostedAugust 19, 2025
UpdatedSeptember 4, 2025
ByMy Patient Advice

The connection between ADHD and anxiety isn’t just behavioural,  it’s embedded in biology. Studies on ADHD and anxiety genetics reveal a strong genetic correlation, helping to explain why many individuals experience both conditions simultaneously. 

This comorbidity often begins in childhood and can continue into adulthood, affecting emotional regulation, attention, and overall mental health. Understanding the genetic link helps clarify why dual diagnoses are common and how they should be treated in tandem. 

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The genetic link between ADHD and anxiety 

Here’s how shared genetics shape the overlap between ADHD and anxiety disorders. 

Genetic correlation 

Twin and family studies show a significant genetic correlation between ADHD and anxiety, indicating that some of the same inherited traits increase the likelihood of developing both conditions. 

Mental health comorbidity 

ADHD often coexists with other conditions. Shared genetic influences on brain structure and neurotransmitter function help explain this mental health comorbidity, particularly in areas tied to impulse control and emotional regulation. 

Anxiety risk in ADHD profiles 

Some genetic markers associated with ADHD also elevate anxiety risk, especially those affecting the stress response system. This increases susceptibility to worry, nervousness, and overthinking, common in both conditions. 

Understanding the interplay of ADHD and anxiety genetics allows for earlier, more targeted treatment strategies. Visit providers like ADHD Certify for integrated evaluations that address both attention and anxiety challenges. 

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Genetic Factors in ADHD. 

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Lucia Alvarez, MSc, author for my patient advice - mypatientadvice.co.uk

Lucia Alvarez, MSc

Author

Lucia Alvarez is a clinical psychologist with a Master’s in Clinical Psychology and extensive experience providing evidence-based therapy and psychological assessment to children, adolescents, and adults. Skilled in CBT, DBT, and other therapeutic interventions, she has worked in hospital, community, and residential care settings. Her expertise includes grief counseling, anxiety management, and resilience-building, with a strong focus on creating safe, supportive environments to improve mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy. 

Dr. Rebecca Fernandez, MBBS, author and a reviewer for my patient advice - mypatientadvice.co.uk

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy. 

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