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How do genetic factors influence the development of ADHD? 

PostedAugust 18, 2025
UpdatedAugust 18, 2025
ByMy Patient Advice

The development of ADHD is shaped by complex interactions between genes and the brain. Studies increasingly show that specific ADHD development genes contribute to how attention, impulse control, and emotional regulation take shape in early childhood. These genes influence neural circuits and chemical messengers, especially those involving dopamine, that are central to ADHD behaviour. 

While no single gene is responsible, clusters of genetic variants have been identified that impact how efficiently the brain’s executive functions operate. This genetic influence begins well before birth and continues to shape attention and behaviour through development. 

Genetic mechanisms at work in ADHD 

Here are the keyways genetic science explains ADHD risk and expression. 

Gene expression ADHD 

Genes involved in dopamine transmission and brain plasticity can be switched “on” or “off” by environmental factors. This dynamic interaction helps explain why ADHD may appear more strongly in some children than others, even within the same family. 

ADHD brain pathways 

Genetic variation can influence structural and functional changes in brain areas such as the prefrontal cortex and basal ganglia. These regions are responsible for planning, decision-making and behavioural inhibition, core difficulties in ADHD. 

ADHD inheritance 

Children with a family history of ADHD are more likely to inherit these risk gene patterns. This makes ADHD development genes a central concern when evaluating early behavioural issues and planning interventions. 

Understanding the role of genetics in ADHD not only deepens scientific insight but also leads to more nuanced, early-stage intervention. Visit providers like ADHD Certify for comprehensive assessments that consider family history, brain development and personalised support. 

For a deeper dive into the science, diagnosis, and full treatment landscape, read our complete guide to Genetic Factors in ADHD. 

Lucia Alvarez, MSc, author for my patient advice - mypatientadvice.co.uk

Lucia Alvarez, MSc

Author

Lucia Alvarez is a clinical psychologist with a Master’s in Clinical Psychology and extensive experience providing evidence-based therapy and psychological assessment to children, adolescents, and adults. Skilled in CBT, DBT, and other therapeutic interventions, she has worked in hospital, community, and residential care settings. Her expertise includes grief counseling, anxiety management, and resilience-building, with a strong focus on creating safe, supportive environments to improve mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the author's privacy. 

Dr. Rebecca Fernandez, MBBS, author and a reviewer for my patient advice - mypatientadvice.co.uk

Dr. Rebecca Fernandez, MBBS

Reviewer

Dr. Rebecca Fernandez is a UK-trained physician with an MBBS and experience in general surgery, cardiology, internal medicine, gynecology, intensive care, and emergency medicine. She has managed critically ill patients, stabilised acute trauma cases, and provided comprehensive inpatient and outpatient care. In psychiatry, Dr. Fernandez has worked with psychotic, mood, anxiety, and substance use disorders, applying evidence-based approaches such as CBT, ACT, and mindfulness-based therapies. Her skills span patient assessment, treatment planning, and the integration of digital health solutions to support mental well-being.

All qualifications and professional experience stated above are authentic and verified by our editorial team. However, pseudonym and image likeness are used to protect the reviewer's privacy. 

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